The RADAR repository: a resource for studies of infectious agents and their transmissibility by transfusion
Identifieur interne : 001007 ( Main/Exploration ); précédent : 001006; suivant : 001008The RADAR repository: a resource for studies of infectious agents and their transmissibility by transfusion
Auteurs : S. H. Kleinman [États-Unis] ; S. A. Glynn [États-Unis] ; M. J. Higgins [États-Unis] ; D. J. Triulzi [États-Unis] ; J. W. Smith [États-Unis] ; C. C. Nass [États-Unis] ; George Garratty [États-Unis] ; E. L. Murphy [États-Unis] ; G. F. Leparc [États-Unis] ; G. B. Schreiber [États-Unis] ; M. R. King [États-Unis] ; M. E. Chamberland [États-Unis] ; G. J. Nemo [États-Unis]Source :
- Transfusion [ 0041-1132 ] ; 2005-07.
English descriptors
- Teeft :
- Aliquot, Allogeneic, Allogeneic donors, Anonymized fashion, Assay, Autologous, Autologous donors, Baseline, Baseline transmission rate, Blood center, Blood centers, Blood donations, Blood institute, Blood services, Blood types, California region, Central repository, Clinical services, Disease control, Donation, Donation repository, Donation specimens, Donor, Donor exposures, Donor population, Donor prevalence, Donor specimens, Enrollment, Florida blood services, Future testing, Goldman center, Greater chesapeake, Hbsag, Hepatitis, Htlv, Human virus, Human virus type, Infection, Infectious agents, Infectious units, Initial nonenrollment, Interquartile range, John hospital, Johns hopkins university hospital, July, Kleinman, Leukoreduced rbcs, Mary hospital, Medical center, Michigan region, National heart, Negative result, Nucleic acid, Oklahoma blood institute, Oklahoma city, Orthopedic surgery patients, Particular agent, Positive result, Positive results, Posttransfusion, Posttransfusion specimens, Potomac region, Pretransfusion, Pretransfusion specimen, Pretransfusion specimens, Prevalence, Previous repositories, Radar baseline, Radar components, Radar donation exposures, Radar donation specimens, Radar recipients, Radar repository, Radar unit, Radar units, Rbc, Recipient, Recipient enrollment, Recipient population, Recipient testing, Reds blood centers, Reds centers, Repository, Repository specimens, Samaritan hospital, Sample sizes, Second specimen, Specimen, Statistical power, Study design, Supplementary testing, Transfusion, Transfusion medicine, Transfusion medicine community, Transfusion recipients, Transfusion transmissibility, Transfusion transmission, Transfusion transmission rate, Transfusion volume, Transmissibility, Transmissibility rate, Transmission rate, Ttvi, Ttvi prevalence, Ttvi rates, Ttvi results, Viral infections, Virus infection, Virus type, West nile virus.
Abstract
BACKGROUND: An ongoing issue in transfusion medicine is whether newly identified or emerging pathogens can be transmitted by transfusion. One method to study this question is through the use of a contemporary linked donor‐recipient repository. STUDY DESIGN AND METHODS: The Retrovirus Epidemiology Donor Study Allogeneic Donor and Recipient (RADAR) repository was established between 2000 and 2003 by seven blood centers and eight collaborating hospitals. Specimens from consented donors were collected, components from their donations were routed to participating hospitals, and recipients of these units gave enrollment and follow‐up specimens for long‐term storage. The repository was designed to show that zero transmissions to enrolled recipients would indicate with 95 percent confidence that the transfusion transmission rate of an agent with prevalence of 0.05 to 1 percent was lower than 25 percent. RESULTS: The repository contains pre‐ and posttransfusion specimens from 3,575 cardiac, vascular, and orthopedic surgery patients, linked to 13,201 donation specimens. The mean number of RADAR donation exposures per recipient is 3.85. The distribution of components transfused is 77 percent red cells, 13 percent whole blood–derived platelet concentrates, and 10 percent fresh frozen plasma. A supplementary unlinked donation repository containing 99,906 specimens from 84,339 donors was also established and can be used to evaluate the prevalence of an agent and validate assay(s) performance before accessing the donor‐recipient–linked repository. Recipient testing conducted during the establishment of RADAR revealed no transmissions of human immunodeficiency virus, hepatitis C virus, or human T‐lymphotropic virus. CONCLUSIONS: RADAR is a contemporary donor‐recipient repository that can be accessed to study the transfusion transmissibility of emerging agents.
Url:
DOI: 10.1111/j.1537-2995.2005.00171.x
Affiliations:
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Le document en format XML
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Nass</name></author><author><name sortKey="Garratty, George" sort="Garratty, George" uniqKey="Garratty G" first="George" last="Garratty">George Garratty</name></author><author><name sortKey="Murphy, E L" sort="Murphy, E L" uniqKey="Murphy E" first="E. L." last="Murphy">E. L. Murphy</name></author><author><name sortKey="Leparc, G F" sort="Leparc, G F" uniqKey="Leparc G" first="G. F." last="Leparc">G. F. Leparc</name></author><author><name sortKey="Schreiber, G B" sort="Schreiber, G B" uniqKey="Schreiber G" first="G. B." last="Schreiber">G. B. Schreiber</name></author><author><name sortKey="King, M R" sort="King, M R" uniqKey="King M" first="M. R." last="King">M. R. King</name></author><author><name sortKey="Chamberland, M E" sort="Chamberland, M E" uniqKey="Chamberland M" first="M. E." last="Chamberland">M. E. Chamberland</name></author><author><name sortKey="Nemo, G J" sort="Nemo, G J" uniqKey="Nemo G" first="G. J." last="Nemo">G. J. 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H." last="Kleinman">S. H. Kleinman</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>From Westat, Rockville, Maryland; the American Red Cross Blood Services Southeastern Michigan Region, Detroit, Michigan; the Institute for Transfusion Medicine, Pittsburgh, Pennsylvania; Sylvan N. Goldman Center, Oklahoma Blood Institute, Oklahoma City, Oklahoma; the American Red Cross Blood Services, Greater Chesapeake and Potomac Region, Baltimore, Maryland; the American Red Cross Blood Services Southern California Region, Los Angeles, California; the Blood Systems Research Institute, San Francisco, California; the University of California, San Francisco, California; Florida Blood Services, St Petersburg, Florida; the Centers for Disease Control and Prevention, Atlanta, Georgia; and the Division of Blood Diseases & Resources, Blood Resources Branch, National Heart, Lung, and Blood Institute, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Glynn, S A" sort="Glynn, S A" uniqKey="Glynn S" first="S. A." last="Glynn">S. A. Glynn</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>From Westat, Rockville, Maryland; the American Red Cross Blood Services Southeastern Michigan Region, Detroit, Michigan; the Institute for Transfusion Medicine, Pittsburgh, Pennsylvania; Sylvan N. Goldman Center, Oklahoma Blood Institute, Oklahoma City, Oklahoma; the American Red Cross Blood Services, Greater Chesapeake and Potomac Region, Baltimore, Maryland; the American Red Cross Blood Services Southern California Region, Los Angeles, California; the Blood Systems Research Institute, San Francisco, California; the University of California, San Francisco, California; Florida Blood Services, St Petersburg, Florida; the Centers for Disease Control and Prevention, Atlanta, Georgia; and the Division of Blood Diseases & Resources, Blood Resources Branch, National Heart, Lung, and Blood Institute, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Higgins, M J" sort="Higgins, M J" uniqKey="Higgins M" first="M. J." last="Higgins">M. J. Higgins</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>From Westat, Rockville, Maryland; the American Red Cross Blood Services Southeastern Michigan Region, Detroit, Michigan; the Institute for Transfusion Medicine, Pittsburgh, Pennsylvania; Sylvan N. Goldman Center, Oklahoma Blood Institute, Oklahoma City, Oklahoma; the American Red Cross Blood Services, Greater Chesapeake and Potomac Region, Baltimore, Maryland; the American Red Cross Blood Services Southern California Region, Los Angeles, California; the Blood Systems Research Institute, San Francisco, California; the University of California, San Francisco, California; Florida Blood Services, St Petersburg, Florida; the Centers for Disease Control and Prevention, Atlanta, Georgia; and the Division of Blood Diseases & Resources, Blood Resources Branch, National Heart, Lung, and Blood Institute, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Triulzi, D J" sort="Triulzi, D J" uniqKey="Triulzi D" first="D. J." last="Triulzi">D. J. Triulzi</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>From Westat, Rockville, Maryland; the American Red Cross Blood Services Southeastern Michigan Region, Detroit, Michigan; the Institute for Transfusion Medicine, Pittsburgh, Pennsylvania; Sylvan N. Goldman Center, Oklahoma Blood Institute, Oklahoma City, Oklahoma; the American Red Cross Blood Services, Greater Chesapeake and Potomac Region, Baltimore, Maryland; the American Red Cross Blood Services Southern California Region, Los Angeles, California; the Blood Systems Research Institute, San Francisco, California; the University of California, San Francisco, California; Florida Blood Services, St Petersburg, Florida; the Centers for Disease Control and Prevention, Atlanta, Georgia; and the Division of Blood Diseases & Resources, Blood Resources Branch, National Heart, Lung, and Blood Institute, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Smith, J W" sort="Smith, J W" uniqKey="Smith J" first="J. W." last="Smith">J. W. Smith</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>From Westat, Rockville, Maryland; the American Red Cross Blood Services Southeastern Michigan Region, Detroit, Michigan; the Institute for Transfusion Medicine, Pittsburgh, Pennsylvania; Sylvan N. Goldman Center, Oklahoma Blood Institute, Oklahoma City, Oklahoma; the American Red Cross Blood Services, Greater Chesapeake and Potomac Region, Baltimore, Maryland; the American Red Cross Blood Services Southern California Region, Los Angeles, California; the Blood Systems Research Institute, San Francisco, California; the University of California, San Francisco, California; Florida Blood Services, St Petersburg, Florida; the Centers for Disease Control and Prevention, Atlanta, Georgia; and the Division of Blood Diseases & Resources, Blood Resources Branch, National Heart, Lung, and Blood Institute, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Nass, C C" sort="Nass, C C" uniqKey="Nass C" first="C. C." last="Nass">C. C. Nass</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>From Westat, Rockville, Maryland; the American Red Cross Blood Services Southeastern Michigan Region, Detroit, Michigan; the Institute for Transfusion Medicine, Pittsburgh, Pennsylvania; Sylvan N. Goldman Center, Oklahoma Blood Institute, Oklahoma City, Oklahoma; the American Red Cross Blood Services, Greater Chesapeake and Potomac Region, Baltimore, Maryland; the American Red Cross Blood Services Southern California Region, Los Angeles, California; the Blood Systems Research Institute, San Francisco, California; the University of California, San Francisco, California; Florida Blood Services, St Petersburg, Florida; the Centers for Disease Control and Prevention, Atlanta, Georgia; and the Division of Blood Diseases & Resources, Blood Resources Branch, National Heart, Lung, and Blood Institute, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Garratty, George" sort="Garratty, George" uniqKey="Garratty G" first="George" last="Garratty">George Garratty</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>From Westat, Rockville, Maryland; the American Red Cross Blood Services Southeastern Michigan Region, Detroit, Michigan; the Institute for Transfusion Medicine, Pittsburgh, Pennsylvania; Sylvan N. Goldman Center, Oklahoma Blood Institute, Oklahoma City, Oklahoma; the American Red Cross Blood Services, Greater Chesapeake and Potomac Region, Baltimore, Maryland; the American Red Cross Blood Services Southern California Region, Los Angeles, California; the Blood Systems Research Institute, San Francisco, California; the University of California, San Francisco, California; Florida Blood Services, St Petersburg, Florida; the Centers for Disease Control and Prevention, Atlanta, Georgia; and the Division of Blood Diseases & Resources, Blood Resources Branch, National Heart, Lung, and Blood Institute, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Murphy, E L" sort="Murphy, E L" uniqKey="Murphy E" first="E. L." last="Murphy">E. L. Murphy</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>From Westat, Rockville, Maryland; the American Red Cross Blood Services Southeastern Michigan Region, Detroit, Michigan; the Institute for Transfusion Medicine, Pittsburgh, Pennsylvania; Sylvan N. Goldman Center, Oklahoma Blood Institute, Oklahoma City, Oklahoma; the American Red Cross Blood Services, Greater Chesapeake and Potomac Region, Baltimore, Maryland; the American Red Cross Blood Services Southern California Region, Los Angeles, California; the Blood Systems Research Institute, San Francisco, California; the University of California, San Francisco, California; Florida Blood Services, St Petersburg, Florida; the Centers for Disease Control and Prevention, Atlanta, Georgia; and the Division of Blood Diseases & Resources, Blood Resources Branch, National Heart, Lung, and Blood Institute, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Leparc, G F" sort="Leparc, G F" uniqKey="Leparc G" first="G. F." last="Leparc">G. F. Leparc</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>From Westat, Rockville, Maryland; the American Red Cross Blood Services Southeastern Michigan Region, Detroit, Michigan; the Institute for Transfusion Medicine, Pittsburgh, Pennsylvania; Sylvan N. Goldman Center, Oklahoma Blood Institute, Oklahoma City, Oklahoma; the American Red Cross Blood Services, Greater Chesapeake and Potomac Region, Baltimore, Maryland; the American Red Cross Blood Services Southern California Region, Los Angeles, California; the Blood Systems Research Institute, San Francisco, California; the University of California, San Francisco, California; Florida Blood Services, St Petersburg, Florida; the Centers for Disease Control and Prevention, Atlanta, Georgia; and the Division of Blood Diseases & Resources, Blood Resources Branch, National Heart, Lung, and Blood Institute, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Schreiber, G B" sort="Schreiber, G B" uniqKey="Schreiber G" first="G. B." last="Schreiber">G. B. Schreiber</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>From Westat, Rockville, Maryland; the American Red Cross Blood Services Southeastern Michigan Region, Detroit, Michigan; the Institute for Transfusion Medicine, Pittsburgh, Pennsylvania; Sylvan N. Goldman Center, Oklahoma Blood Institute, Oklahoma City, Oklahoma; the American Red Cross Blood Services, Greater Chesapeake and Potomac Region, Baltimore, Maryland; the American Red Cross Blood Services Southern California Region, Los Angeles, California; the Blood Systems Research Institute, San Francisco, California; the University of California, San Francisco, California; Florida Blood Services, St Petersburg, Florida; the Centers for Disease Control and Prevention, Atlanta, Georgia; and the Division of Blood Diseases & Resources, Blood Resources Branch, National Heart, Lung, and Blood Institute, Bethesda</wicri:cityArea></affiliation><affiliation></affiliation></author><author><name sortKey="King, M R" sort="King, M R" uniqKey="King M" first="M. R." last="King">M. R. King</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>From Westat, Rockville, Maryland; the American Red Cross Blood Services Southeastern Michigan Region, Detroit, Michigan; the Institute for Transfusion Medicine, Pittsburgh, Pennsylvania; Sylvan N. Goldman Center, Oklahoma Blood Institute, Oklahoma City, Oklahoma; the American Red Cross Blood Services, Greater Chesapeake and Potomac Region, Baltimore, Maryland; the American Red Cross Blood Services Southern California Region, Los Angeles, California; the Blood Systems Research Institute, San Francisco, California; the University of California, San Francisco, California; Florida Blood Services, St Petersburg, Florida; the Centers for Disease Control and Prevention, Atlanta, Georgia; and the Division of Blood Diseases & Resources, Blood Resources Branch, National Heart, Lung, and Blood Institute, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Chamberland, M E" sort="Chamberland, M E" uniqKey="Chamberland M" first="M. E." last="Chamberland">M. E. Chamberland</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>From Westat, Rockville, Maryland; the American Red Cross Blood Services Southeastern Michigan Region, Detroit, Michigan; the Institute for Transfusion Medicine, Pittsburgh, Pennsylvania; Sylvan N. Goldman Center, Oklahoma Blood Institute, Oklahoma City, Oklahoma; the American Red Cross Blood Services, Greater Chesapeake and Potomac Region, Baltimore, Maryland; the American Red Cross Blood Services Southern California Region, Los Angeles, California; the Blood Systems Research Institute, San Francisco, California; the University of California, San Francisco, California; Florida Blood Services, St Petersburg, Florida; the Centers for Disease Control and Prevention, Atlanta, Georgia; and the Division of Blood Diseases & Resources, Blood Resources Branch, National Heart, Lung, and Blood Institute, Bethesda</wicri:cityArea></affiliation></author><author><name sortKey="Nemo, G J" sort="Nemo, G J" uniqKey="Nemo G" first="G. J." last="Nemo">G. J. Nemo</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>From Westat, Rockville, Maryland; the American Red Cross Blood Services Southeastern Michigan Region, Detroit, Michigan; the Institute for Transfusion Medicine, Pittsburgh, Pennsylvania; Sylvan N. Goldman Center, Oklahoma Blood Institute, Oklahoma City, Oklahoma; the American Red Cross Blood Services, Greater Chesapeake and Potomac Region, Baltimore, Maryland; the American Red Cross Blood Services Southern California Region, Los Angeles, California; the Blood Systems Research Institute, San Francisco, California; the University of California, San Francisco, California; Florida Blood Services, St Petersburg, Florida; the Centers for Disease Control and Prevention, Atlanta, Georgia; and the Division of Blood Diseases & Resources, Blood Resources Branch, National Heart, Lung, and Blood Institute, Bethesda</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Transfusion</title><title level="j" type="alt">TRANSFUSION</title><idno type="ISSN">0041-1132</idno><idno type="eISSN">1537-2995</idno><imprint><biblScope unit="vol">45</biblScope><biblScope unit="issue">7</biblScope><biblScope unit="page" from="1073">1073</biblScope><biblScope unit="page" to="1083">1083</biblScope><biblScope unit="page-count">11</biblScope><publisher>Blackwell Science Inc</publisher><pubPlace>Oxford, UK and Malden, USA</pubPlace><date type="published" when="2005-07">2005-07</date></imprint><idno type="ISSN">0041-1132</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0041-1132</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Aliquot</term><term>Allogeneic</term><term>Allogeneic donors</term><term>Anonymized fashion</term><term>Assay</term><term>Autologous</term><term>Autologous donors</term><term>Baseline</term><term>Baseline transmission rate</term><term>Blood center</term><term>Blood centers</term><term>Blood donations</term><term>Blood institute</term><term>Blood services</term><term>Blood types</term><term>California region</term><term>Central repository</term><term>Clinical services</term><term>Disease control</term><term>Donation</term><term>Donation repository</term><term>Donation specimens</term><term>Donor</term><term>Donor exposures</term><term>Donor population</term><term>Donor prevalence</term><term>Donor specimens</term><term>Enrollment</term><term>Florida blood services</term><term>Future testing</term><term>Goldman center</term><term>Greater chesapeake</term><term>Hbsag</term><term>Hepatitis</term><term>Htlv</term><term>Human virus</term><term>Human virus type</term><term>Infection</term><term>Infectious agents</term><term>Infectious units</term><term>Initial nonenrollment</term><term>Interquartile range</term><term>John hospital</term><term>Johns hopkins university hospital</term><term>July</term><term>Kleinman</term><term>Leukoreduced rbcs</term><term>Mary hospital</term><term>Medical center</term><term>Michigan region</term><term>National heart</term><term>Negative result</term><term>Nucleic acid</term><term>Oklahoma blood institute</term><term>Oklahoma city</term><term>Orthopedic surgery patients</term><term>Particular agent</term><term>Positive result</term><term>Positive results</term><term>Posttransfusion</term><term>Posttransfusion specimens</term><term>Potomac region</term><term>Pretransfusion</term><term>Pretransfusion specimen</term><term>Pretransfusion specimens</term><term>Prevalence</term><term>Previous repositories</term><term>Radar baseline</term><term>Radar components</term><term>Radar donation exposures</term><term>Radar donation specimens</term><term>Radar recipients</term><term>Radar repository</term><term>Radar unit</term><term>Radar units</term><term>Rbc</term><term>Recipient</term><term>Recipient enrollment</term><term>Recipient population</term><term>Recipient testing</term><term>Reds blood centers</term><term>Reds centers</term><term>Repository</term><term>Repository specimens</term><term>Samaritan hospital</term><term>Sample sizes</term><term>Second specimen</term><term>Specimen</term><term>Statistical power</term><term>Study design</term><term>Supplementary testing</term><term>Transfusion</term><term>Transfusion medicine</term><term>Transfusion medicine community</term><term>Transfusion recipients</term><term>Transfusion transmissibility</term><term>Transfusion transmission</term><term>Transfusion transmission rate</term><term>Transfusion volume</term><term>Transmissibility</term><term>Transmissibility rate</term><term>Transmission rate</term><term>Ttvi</term><term>Ttvi prevalence</term><term>Ttvi rates</term><term>Ttvi results</term><term>Viral infections</term><term>Virus infection</term><term>Virus type</term><term>West nile virus</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">BACKGROUND: An ongoing issue in transfusion medicine is whether newly identified or emerging pathogens can be transmitted by transfusion. One method to study this question is through the use of a contemporary linked donor‐recipient repository. STUDY DESIGN AND METHODS: The Retrovirus Epidemiology Donor Study Allogeneic Donor and Recipient (RADAR) repository was established between 2000 and 2003 by seven blood centers and eight collaborating hospitals. Specimens from consented donors were collected, components from their donations were routed to participating hospitals, and recipients of these units gave enrollment and follow‐up specimens for long‐term storage. The repository was designed to show that zero transmissions to enrolled recipients would indicate with 95 percent confidence that the transfusion transmission rate of an agent with prevalence of 0.05 to 1 percent was lower than 25 percent. RESULTS: The repository contains pre‐ and posttransfusion specimens from 3,575 cardiac, vascular, and orthopedic surgery patients, linked to 13,201 donation specimens. The mean number of RADAR donation exposures per recipient is 3.85. The distribution of components transfused is 77 percent red cells, 13 percent whole blood–derived platelet concentrates, and 10 percent fresh frozen plasma. A supplementary unlinked donation repository containing 99,906 specimens from 84,339 donors was also established and can be used to evaluate the prevalence of an agent and validate assay(s) performance before accessing the donor‐recipient–linked repository. Recipient testing conducted during the establishment of RADAR revealed no transmissions of human immunodeficiency virus, hepatitis C virus, or human T‐lymphotropic virus. CONCLUSIONS: RADAR is a contemporary donor‐recipient repository that can be accessed to study the transfusion transmissibility of emerging agents.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Maryland</li></region></list><tree><country name="États-Unis"><region name="Maryland"><name sortKey="Kleinman, S H" sort="Kleinman, S H" uniqKey="Kleinman S" first="S. H." last="Kleinman">S. H. Kleinman</name></region><name sortKey="Chamberland, M E" sort="Chamberland, M E" uniqKey="Chamberland M" first="M. E." last="Chamberland">M. E. Chamberland</name><name sortKey="Garratty, George" sort="Garratty, George" uniqKey="Garratty G" first="George" last="Garratty">George Garratty</name><name sortKey="Glynn, S A" sort="Glynn, S A" uniqKey="Glynn S" first="S. A." last="Glynn">S. A. Glynn</name><name sortKey="Higgins, M J" sort="Higgins, M J" uniqKey="Higgins M" first="M. J." last="Higgins">M. J. Higgins</name><name sortKey="King, M R" sort="King, M R" uniqKey="King M" first="M. R." last="King">M. R. King</name><name sortKey="Leparc, G F" sort="Leparc, G F" uniqKey="Leparc G" first="G. F." last="Leparc">G. F. Leparc</name><name sortKey="Murphy, E L" sort="Murphy, E L" uniqKey="Murphy E" first="E. L." last="Murphy">E. L. Murphy</name><name sortKey="Nass, C C" sort="Nass, C C" uniqKey="Nass C" first="C. C." last="Nass">C. C. Nass</name><name sortKey="Nemo, G J" sort="Nemo, G J" uniqKey="Nemo G" first="G. J." last="Nemo">G. J. Nemo</name><name sortKey="Schreiber, G B" sort="Schreiber, G B" uniqKey="Schreiber G" first="G. B." last="Schreiber">G. B. Schreiber</name><name sortKey="Smith, J W" sort="Smith, J W" uniqKey="Smith J" first="J. W." last="Smith">J. W. Smith</name><name sortKey="Triulzi, D J" sort="Triulzi, D J" uniqKey="Triulzi D" first="D. J." last="Triulzi">D. J. Triulzi</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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